Ctriporin, derived from the venom of the scorpion Chaerilus tricostatus is a new antimicrobial peptide (AMP) is effective at inhibiting growth of gram positive bacteria and other antibiotic-resistant pathogens acts using the bactericidal mechanism of the rapid cell lysis.
Antisense antibacterials target a specific sequence in the mRNA and inhibits the binding of bacterial DNA-dependent RNA polymerase and causes cell death
BUT WHAT ABOUT GRAM-NEGATIVE BACTERIAL INFECTIONS?
Examples of gram-negative bacteria:
acinetobacter
pseudomonas
carbapenemase-resistant Enterobacteriaceae
Escherichia coli (E. coli)
Gram-negative bacteria lack the target substrates of teixobactin and contain an outer barrier, which make them resistant to teixobactin.
Further research of microorganisms in soil utilizing the iChip method may produce antibiotics that will be able to specifically target gram-negative bacteria.